Generian is dedicated to developing medicines that are effective in treating a wide range of rare and common conditions by discovering first-in-class small molecules that activate large, coordinated protein networks to help reset and restore cellular homeostasis. The company has two lead programs and a healthy pipeline of additional targets. Generian is headquartered in Cambridge MA, having been spun out of the University of Pittsburgh in 2019. The company has Series A funding from UPMC Enterprises and, while currently in stealth mode, expects to formally launch in 4Q2020. Generian is currently a small, nimble team. Corporate culture and professional development are as important to us as meeting our development objectives.
The Company is seeking an Associate Director or Director of Pharmacology and Translational Medicine (level commensurate with experience) with prior first-in-class small molecule program experience. The candidate will report to the VP of Translation & Development.
Key responsibilities for candidate:
- Develop and execute translational pharmacology and biomarker development plans for at least two assets in indications spanning neurodegenerative, metabolic, and lysosomal storage disorders, with the goal of developing early preclinical and clinical proof of concept data packages.
- Conduct hands on design of studies, review of outside vendors, vendor management and results interpretation and drive necessary operational processes to support study execution.
- Develop and maintain a robust PK/PD platform for the various programs.
- Support the team in driving the corresponding IP strategy as the sciences and programs evolve.
- Contribute to the definition, articulation, and execution of Generian’s scientific vision and strategy.
- Develop and apply in-depth knowledge of therapeutic areas, emerging relevant preclinical and clinical research, product and competitive landscapes including current treatment strategies, current and potential competitors, and new therapeutic developments.
- Build and maintain strong relationships with opinion leaders, collaborators, scientific advisors, alliance partners and patient advocacy groups in order to help drive the scientific communications program and to ensure that team meets scientific and business objectives.
This person should be located in Boston/Cambridge, MA. Generian will provide private office space convenient for the candidate and for corporate strategic purposes. The candidate should expect to travel to Pittsburgh on a quarterly basis when circumstances return to normal operations. Generian employees currently have the option of working from home or working from private offices, while following the safety precautions in place at those offices. Generian does not yet have a date when required travel or in-office presence will be necessary because it remains unclear when this will be safe for all employees.
Flexible working hours; competitive salary and benefits commensurate with experience.
The ideal candidate embraces risk in developing life changing medicines, is never content with the status quo, and possess a rare balance of confidence and humility. He/She should be organizationally savvy and socially adept, capable of working with a variety of stakeholders including academics, vendors, investors, and pharma partners.
Required experience or qualifications:
- PhD in a biological discipline such as pharmacology, biochemistry, physiology, molecular biology
- Experienced drug developer with at least 5 years' experience in the drug development process, with particular in-depth know how and experience in the early development space
- Pharma/biotech experience with a focus on the translational aspects of moving programs through preclinical development and into clinical proof-of-concept
- Extensive prior experience designing, commissioning, and monitoring preclinical pharmacology studies with CROs and academic groups
- Keen understanding of translational development strategies that leverage biomarkers to de-risk assets in preclinical and early clinical trials
- Demonstrated ability to objectively assess data sets, make informed decisions and take action in the face of uncertainty
- Ability to effectively and seamlessly multi-task, and prioritize across multiple exploratory development assets, with complex strategies and accelerated development timelines
- Demonstrated ability to successfully and effectively cooperate, collaborate and work across functional boundaries.
Preferred experience or qualifications:
- Development experience for programs across multiple therapeutic areas is a plus
- Experience developing assets directly out of an academic setting is desirable
- Expertise in the discovery and development of novel biomarker approaches
- Assay experience in the areas of autophagy induction, energetic stress, metabolism, and mitochondrial health
- Entrepreneurial, innovative thinker with the ability to think big picture (scientific and strategic) as well as to attend to technical detail
- Thorough and detail-oriented with a commitment to outcomes and a strong sense of urgency
- Ability to comply with rigorous scientific methodology standards and present findings for peer review
- Ability to move in a fast-paced and nimble environment
- This will be a very hands-on role, and the incumbent will be an integral part of the team; the ability to roll up sleeves and get things done is paramount.
Candidates should send expressions of interest to email@example.com.
Location/Region: Cambridge, MA